4-氯-3-三氟甲基-5-甲基吡唑合成路线 （共 3 条）
反应条件
N-chloro-succinimide in DMF (N,N-dimethyl-formamide) T=70°C; 22 h;
参考文献
WO2003/105853 A1, ;
Page 64 ;
WO 03/105853 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 55 °C 2: lithium hydroxide hydrate; water / tetrahydrofuran / 5 h / 60 °C View Scheme
反应条件
potassium carbonate in N,N-dimethyl-formamide T=55°C; 10 h;
参考文献
ChemoCentryx, Inc.; Chen, Xi; Dragoli, Dean R.; Fan, Pingchen; Li, Yandong; Powers, Jay P.; Punna, Sreenivas; Tanaka, Hiroko; Zhang, Penglie
Patent: US2014/57937 A1, 2014 ;
Location in patent: Paragraph 0093; 0094 ;
