1,4-二氧杂螺[4.5]癸-8-基4-甲基苯磺酸酯合成路线 （共 2 条）
反应条件
pyridine
T=20°C; 18 h; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; RUPRAH, Parminder, Kaur; MERCHANT, Kevin, John; WALSH, Louise, Marie; KERR, Catrina, Morven; FIELDHOUSE, Charlotte; HARRISSON, David; MAINE, Stephanie; HAZEL, Katherine
Patent: WO2013/27001 A1, 2013 ;
Location in patent: Page/Page column 132-133 ;
反应条件
1: NaBH4 / methanol / 2 h / 0 °C
2: 9.67 g / pyridine / 18 h / 20 °C
View Scheme
参考文献
Kitano, Yoshikazu; Ito, Toshihiro; Suzuki, Takehiro; Nogata, Yasuyuki; Shinshima, Kyouji; Yoshimura, Erina; Chiba, Kazuhiro; Tada, Masahiro; Sakaguchi, Isamu
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 20 p. 2251 - 2255
