3-氨基-2,6-哌啶二酮合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol T=20°C; 2 h;
参考文献
EP1964842 A1, ;
Page/Page column 28 ;
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 421 - 425
反应条件
1: TEA; HOBT; trifluoroacetamide / EDC / CH2Cl2 2: TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 421 - 425
反应条件
acetic acid RefluxMolecular sieve;
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881
反应条件
1: With sodium carbonate in acetonitrile T=5°C; Inert atmosphereRefluxLarge scale; 2: With hydrogenchloride in water T=20 - 62°C; pH=< 6; 4 h; Large scale;
参考文献
CELGENE CORPORATION; LI, Ying; XU, Jean; KLOPFER, Kevin, J.
Patent: WO2013/126394 A1, 2013 ;
Location in patent: Paragraph 00123-00125 ;
反应条件
acetic acid
RefluxMolecular sieve;
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881
