3-甲基-1-乙酰基-1H-吲哚合成路线 （共 20 条）
反应条件
1: 75 percent / Et3N / diethyl ether / 1.) 0 deg C, 1 h, 2.) room temperature, overnight
2: 70 percent / Pd(OAc)2, LiCl, K2CO3 / dimethylformamide / 12 h / 100 °C
3: 87 percent / AlCl3 / CH2Cl2 / 0.5 h / 0 °C / other reagents
View Scheme
参考文献
Larock; Yum; Refvik
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7652 - 7662
反应条件
1: 100 percent / potassium hydroxide / Bu4NBr, 1,2-bis(diphenylphosphino)ethane, bis(dibenzylidenacetone)palladium / CH2Cl2 / 4 h
2: 50 percent / Pd(OAc)2
View Scheme
参考文献
Lebedev, S. A.; Leonova, Yu. P.; Berestova, S. S.; Petrov, E. S.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 5 p. 1005 - 1006
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 5 p. 1112 - 1113
反应条件
Grubb's 2nd generation catalyst in toluene
1 h; Reflux;
参考文献
Kasaya, Yayoi; Hoshi, Kosuke; Terada, Yukiyoshi; Nishida, Atsushi; Shuto, Satoshi; Arisawa, Mitsuhiro
European Journal of Organic Chemistry, 2009 , # 27 p. 4606 - 4613
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
1 h; Heating; Yield given;
参考文献
Dittami, James P.; Ramanatham, Halasya
Tetrahedron Letters, 1988 , vol. 29, # 1 p. 45 - 48
参考文献
Lebedev, S. A.; Leonova, Yu. P.; Berestova, S. S.; Petrov, E. S.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 5 p. 1005 - 1006
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 5 p. 1112 - 1113
参考文献
Oddo
Gazzetta Chimica Italiana, 1913 , vol. 43 II, p. 176
反应条件
sodium hydroxide
1.) CH2Cl2, 3h, 0 deg C; Yield given. Multistep reaction;
参考文献
Pindur, Ulf; Flo, Camran; Akguen, Eyuep; Tunali, Mustafa
Liebigs Annalen der Chemie, 1986 , # 9 p. 1621 - 1627
反应条件
1: 58 percent / chiral ferrocene-based complex; cesium carbonate; hydrogen / [Rh(nbd)2]SbF6 / propan-2-ol / 2 h / 80 °C / 38000 Torr
2: 75 percent / sodium hydroxide; tetrabutylammonium hydrogen sulfate / H2O; benzene / 1 h / 20 °C
View Scheme
参考文献
Kuwano, Ryoichi; Kashiwabara, Manabu; Sato, Koji; Ito, Takashi; Kaneda, Kohei; Ito, Yoshihiko
Tetrahedron Asymmetry, 2006 , vol. 17, # 4 p. 521 - 535
反应条件
1: 48 percent / Pd(OAc)2 / acetic acid / 14 h / Heating
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Itahara, Toshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 5 p. 254 - 255
反应条件
palladium diacetate in acetic acid
16 h; Heating;
参考文献
Itahara, Toshio; Ikeda, Mizue; Sakakibara, Tsutomu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1361 - 1363
