2-氟-2-磷酰基乙酸三乙酯合成路线 （共 33 条）
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; Wittig-Horner Reaction;
2: With bromine in tetrachloromethane
3: With sodium hydroxide in ethanol; water
参考文献
Eddarir, Said; Kajjout, Mohammed; Rolando, Christian
Tetrahedron, 2013 , vol. 69, # 6 p. 1735 - 1738
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran
T=0°C; 1 h;
2: benzoyl chloride in tetrahydrofuran
T=20°C; 4 h;
参考文献
Engman, Mattias; Diesen, Jarle S.; Paptchikhine, Alexander; Andersson, Pher G.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4536 - 4537
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-80°C; 0.25 h;
2: formaldehyd in tetrahydrofuran; hexane
T=-40 - 20°C;
参考文献
Kvicala, Jaroslav; Hrabal, Richard; Czernek, Jiri; Bartosova, Ivana; Paleta, Oldrich; Pelter, Andrew
Journal of Fluorine Chemistry, 2002 , vol. 113, # 2 p. 211 - 218
反应条件
Yield given. Multistep reaction;
参考文献
Thenappan, A.; Burton, D. J.
Journal of Fluorine Chemistry, 1990 , vol. 48, # 1 p. 153 - 157
Title/Abstract View citing articles Show Details
Thenappan, Alagappan; Burton, Donald J.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4639 - 4642
反应条件
n-butyllithium in tetrahydrofuran; hexane
1.) -78 deg C, 20 min, 2.) 40-45 deg C, 18 h;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Journal of Fluorine Chemistry, 1996 , vol. 77, # 1 p. 45 - 50
反应条件
n-butyllithium
1.) THF, -78 deg C, 20 min, 2.) THF, RT, 5 h; Yield given. Multistep reaction;
参考文献
Tsai, Hou-Jen
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 126, p. 1 - 10
反应条件
(i) NaH, Et2O, (ii) /BRN= 635680/; Multistep reaction;
参考文献
NOVARTIS AG; FLOHR, Stefanie; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; RANDL, Stefan, Andreas; VULPETTI, Anna; QUANCARD, Jean
Patent: WO2014/2052 A1, 2014 ;
Location in patent: Page/Page column 58 ;
反应条件
in ethylene glycol dimethyl ether
T=20°C; Horner-Wadsworth-Emmons reaction; 0.5 h;
参考文献
Miyake, Noriaki; Kitazume, Tomoya
Journal of Fluorine Chemistry, 2003 , vol. 122, # 2 p. 243 - 246
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 1 h;
2: butyraldehyde in tetrahydrofuran; hexane
T=20°C;
参考文献
Bargiggia, Frederic; Dos Santos, Sylvia; Piva, Olivier
Synthesis, 2002 , # 3 p. 427 - 437
反应条件
lithium diisopropyl amide in tetrahydrofuran
2 h; Ambient temperature1.) -78 deg C, 1 h; 2.) room temp. 2 h; Yield given;
参考文献
Camps,F.; Coll,J.
Tetrahedron, 1984 , vol. 40, p. 2871
