5-甲基-3-(2-氯苯基)-4-异恶唑甲酸合成路线 （共 10 条）
反应条件
1: 2-chloro-benzaldehyde With hydroxylammonium sulfate in methanol T=20 - 40°C; 1 h; 2: With chlorine; sodium carbonate; triethylamine in methanol T=0 - 20°C; pH=~ 9.5; 24 h; Inert atmosphere; 3: acetoacetic acid methyl ester With sodium carbonate in methanol pH=~ 7 - 7.5;
参考文献
WO2012/164355 A1, ;
Page/Page column 9-10 ;
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1201 - 1204
反应条件
potassium hydroxide in ethanol
参考文献
Journal of the Chemical Society, , p. 5838 - 5845
反应条件
1: Cl2 2: (i) Na, MeOH, (ii) /BRN= 2502600/ 3: aq. KOH / ethanol View Scheme
参考文献
Journal of the Chemical Society, , p. 5838 - 5845
反应条件
1.1: hydroxylammonium sulfate / methanol / 0.5 h 1.2: 0.5 h / pH 8 - 9 / Reflux 2.1: chlorine / methanol / 0 - 5 °C 3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 3.2: 2 h / 0 - 20 °C / pH 9 4.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
phosphorus pentachloride; triethylamine in hexane; dichloromethane; water; isobutyl methylketone
参考文献
Antibioticos, S.A.
Patent: US4230849 A1, 1980 ;
反应条件
1: phosphorus pentachloride / toluene 2: ammonium hydroxide / ethyl acetate / pH 2 - 9 View Scheme
参考文献
VARDHMAN CHEMTECH LIMITED; GUJRAL, Rajinder Singh; JAIN, Suyog
Patent: WO2012/164355 A1, 2012 ;
反应条件
1: SOCl2 2: aq. NaOH, isobutyl methyl ketone View Scheme
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5838 - 5845
反应条件
phosphorus pentachloride T=45°C; 1 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
