2-乙基-1H-吡咯并[2,3-b]吡啶合成路线 （共 4 条）
反应条件
1: With n-butyllithium; potassium tert-butylate in hexanes; diethyl ether T=20°C; 0.666667 h; 2: in hexanes; diethyl ether T=-70°C; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/68418 A1, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/068418 A1
反应条件
1: 2-Methyl-1H-pyrrolo[2,3-b]pyridine With n-butyllithium; potassium tert-butylate in hexanes; diethyl ether T=20°C; 0.666667 h; 2: methyl iodide in hexanes; diethyl ether T=-70°C; 2 h; 3: With water in hexanes; diethyl ether
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/123731 A2, 2005 ;
Location in patent: Page/Page column 50 ;
WO 2005/123731 A2
反应条件
2: sodium ethylate View Scheme
参考文献
Clemo; Swan
Journal of the Chemical Society, 1945 , p. 603,607
反应条件
1: 62 percent / acetic acid; sodium nitrite / H2O / 0.5 h / 20 °C
2: 72 percent / sodium dithionite; sodium hydroxide; ethanol / 0.5 h / Heating
View Scheme
参考文献
Bahekar, Rajesh H.; Jain, Mukul R.; Goel, Ashish; Patel, Dipam N.; Prajapati, Vijay M.; Gupta, Arun A.; Jadav, Pradip A.; Patel, Pankaj R.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3248 - 3265
