1,6-萘并吡啶-5(6H)-酮合成路线 （共 18 条）
反应条件
toluene-4-sulfonic acid in toluene 14 h; Reflux;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 45 ;
US 20120178748 A1
反应条件
1: T=50°C; 2 h; 2: With sodium hydride in N,N-dimethyl-formamide T=80°C; 2.5 h; 3: With hydrogenchloride in water T=0 - 5°C; pH=7.2; 3 h;
参考文献
Showalter, H. D. Hollis
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 5 p. 1311 - 1317
反应条件
potassium carbonate in methanol; diethyl ether; dichloromethane; water; isopropyl alcohol; acetonitrile; benzene
反应条件
1: 52 percent / methanol / 5 h / Heating 2: 73 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 3: 55 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
反应条件
1: 73 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 2: 55 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
反应条件
1.1: 58.5 g / NH3 / CH2Cl2 / 1.58 h / 5 - 15 °C 2.1: 2 h / 50 °C 2.2: NaH / dimethylformamide / 2.5 h / 80 °C 2.3: 48 percent / HCl / H2O / 3 h / 0 - 5 °C / pH 7.2 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 5 p. 1311 - 1317
反应条件
1.1: KOH / methanol; H2O / 6 h / 25 °C 2.1: (COCl)2 / benzene / 19 h / 25 °C 3.1: 58.5 g / NH3 / CH2Cl2 / 1.58 h / 5 - 15 °C 4.1: 2 h / 50 °C 4.2: NaH / dimethylformamide / 2.5 h / 80 °C 4.3: 48 percent / HCl / H2O / 3 h / 0 - 5 °C / pH 7.2 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 5 p. 1311 - 1317
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C 2.1: ammonia / dichloromethane / 18 h / -30 °C 3.1: 2 h / 50 °C 3.2: 2.5 h / 80 °C View Scheme
反应条件
chromium(VI) oxide; acetic acid
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 263,268, 408, 411
反应条件
1: methanol; NH3 2: CrO3; acetic acid View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 263,268, 408, 411
