sodium hydroxide in methanol T=25°C;

1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C 2: palladium on carbon; hydrogen / methanol / 15 h / 20 °C / 760.05 Torr View Scheme

1: 98 percent / 2.5 N NaOH / methanol / 25 °C 2: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5 View Scheme