(S)-(+)-3-(苄氧基羰基)-5-氧代-4-噁唑啉丙酸合成路线 （共 21 条）
反应条件
1: EDC; DMAP / CH2Cl2 2: NaOH / tetrahydrofuran 3: H+ 4: TBAF / tetrahydrofuran View Scheme
参考文献
Pankuch, Jessica J.; Coward, James K.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 12 p. 1561 - 1564
反应条件
sodium methylate in methanol Heating;
参考文献
Bailey, Patrick D.; Bryans, Justin S.
Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2231 - 2234
参考文献
Malachowski; Coward
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7625 - 7634
参考文献
Ko, Kwang-Youn; Lee, Kee-In; Kim, Wan-Loo
Tetrahedron Letters, 1992 , vol. 33, # 44 p. 6651 - 6652
反应条件
1: thionyl chloride / CH2Cl2 / 0.5 h / Heating 2: pyridine / CH2Cl2 / 0.25 h / 20 °C 3: lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 5 °C 4: hydrogen / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 4 p. 1111 - 1118
反应条件
1: 95 percent / NaOMe / methanol / Heating 2: 82 percent / Et3N / CH2Cl2 / -5 °C 3: 85 percent / diethyl ether / -5 °C 4: 97 percent / HCl / diethyl ether / -5 °C 5: 96 percent / NaBH4 / methanol 6: 66 percent / Et3N / CH2Cl2 7: 35 percent / NaH / dimethylformamide / 85 °C 8: K2CO3 / methanol View Scheme
参考文献
Bailey, Patrick D.; Bryans, Justin S.
Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2231 - 2234
反应条件
1: 91 percent / benzyltriethylammonium chloride, K2CO3 / N,N-dimethyl-acetamide / 24 h / 55 °C 2: 82 percent / 1 N NaOH / ethanol View Scheme
参考文献
Loffet, A.; Galeotti, N.; Jouin, P.; Castro, B.
Tetrahedron Letters, 1989 , vol. 30, # 49 p. 6859 - 6860
反应条件
1: methanol 2: 1) ClCO2Et, Et3N / 1) CH2Cl2, 2) Et2O, THF 3: 58 percent / Rh2(OAc)4 / CH2Cl2 View Scheme
参考文献
Ko, Kwang-Youn; Lee, Kee-In; Kim, Wan-Loo
Tetrahedron Letters, 1992 , vol. 33, # 44 p. 6651 - 6652
反应条件
1: 95 percent / NaOMe / methanol / Heating 2: 82 percent / Et3N / CH2Cl2 / -5 °C 3: 85 percent / diethyl ether / -5 °C 4: 97 percent / HCl / diethyl ether / -5 °C 5: 96 percent / NaBH4 / methanol 6: 66 percent / Et3N / CH2Cl2 7: 35 percent / NaH / dimethylformamide / 85 °C 8: K2CO3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 18 p. 2231 - 2234
反应条件
sodium ethanolate
T=0°C; 1.5 h;
参考文献
Malachowski; Coward
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7625 - 7634
