7-氯-4-羟基-5,8-二甲氧基-2-萘羧酸合成路线 （共 2 条）
反应条件
sodium hydroxide; water in tetrahydrofuran; ethanol T=70°C; Hydrolysis; 1 h;
参考文献
Tamiya, Minora; Ohmori, Ken; Kitamura, Mitsuru; Kato, Hirohisa; Arai, Tadamasa; Oorui, Mami; Suzuki, Keisuke
Chemistry - A European Journal, 2007 , vol. 13, # 35 p. 9791 - 9823
反应条件
1: Me2AlCl / CH2Cl2 / 4.5 h / 0 °C 2: K2CO3 / acetone / 13 h / Heating 3: 90 percent / MnO2 / CH2Cl2 / 17 h / 40 °C 4: NaH / tetrahydrofuran 5: H2O; CF3CO2H / 1 h 6: NaOAc / 1 h / Heating 7: 87 percent / H2O; NaOH / tetrahydrofuran; ethanol / 1 h / 70 °C View Scheme
参考文献
Kitamura, Mitsuru; Ohmori, Ken; Kawase, Toshihisa; Suzuki, Keisuke
Angewandte Chemie - International Edition, 1999 , vol. 38, # 9 p. 1229 - 1232
