N-Boc-O-苄基-L-丝氨酸合成路线 （共 43 条）
反应条件
1: t-butyloxycarbonyl-L-serine With sodium hydride in N,N-dimethyl-formamide 2: benzyl bromide in N,N-dimethyl-formamide
参考文献
Gravestock, David; Rousseau, Amanda L.; Lourens, Anna C.U.; Hoppe, Heinrich C.; Nkabinde, Lindiwe A.; Bode, Moira L.
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3225 - 3229
反应条件
ammonium acetate; hydrogen; palladium on activated charcoal in methanol T=20°C; Hydrogenolysis; 3 h;
参考文献
Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996
反应条件
in tetrahydrofuran; water
参考文献
Ramasamy, Kanda S.; Stoisavljevic, Vesna
Nucleosides and Nucleotides, 1999 , vol. 18, # 8 p. 1845 - 1861
反应条件
sodium hydrogencarbonate in water; acetonitrile
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; pH=9.5;
参考文献
Barcelo, Gerard; Senet, Jean-Pierre; Sennyey, Gerard; Bensoam, Jean; Loffet, Albert
Synthesis, 1986 , # 8 p. 627 - 632
反应条件
1: t-butyloxycarbonyl-L-serine With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.583333 h; 2: benzyl-iodide in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 26 p. 4524 - 4534
反应条件
1: potassium hydroxide / 1,4-dioxane; water 2: sodium hydride / N,N-dimethyl-formamide View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 26 p. 3225 - 3229
参考文献
Chemical and pharmaceutical bulletin, , vol. 35, # 2 p. 468 - 478
反应条件
sodium hydroxide; magnesium oxide
参考文献
Chemische Berichte, , vol. 97, p. 2497 - 2503
反应条件
sulfuric acid in water T=75°C; 1 h; Large scale;
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
