2-氯-4-氨基-6,7-二甲氧基喹唑啉合成路线 （共 26 条）
反应条件
in 3-methyl-1-butanol 30 h; Reflux;
参考文献
Cavalli, Andrea; Lizzi, Federica; Bongarzone, Salvatore; Brun, Reto; Luise Krauth-Siegel; Bolognesi, Maria Laura
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3031 - 3035
反应条件
1.1: macroporous polymer-supported carbonate / dimethylsulfoxide / 100 °C 1.2: PS-SH; macroporous polymer-supported isocyanate / dimethylsulfoxide / 60 °C 2.1: macroporous polymer-supported-TsOH / CH2Cl2 / 20 °C 2.2: aq. NH3 / methanol View Scheme
参考文献
Shaw, Yeng-Jeng; Yang, Ya-Ting; Garrison, Jason B; Kyprianou, Natasha; Chen, Ching-Shih
Journal of medicinal chemistry, 2004 , vol. 47, # 18 p. 4453 - 4462
反应条件
1.1: macroporous polymer-supported carbonate / dimethylsulfoxide / 100 °C 1.2: PS-SH; macroporous polymer-supported isocyanate / dimethylsulfoxide / 60 °C 2.1: macroporous polymer-supported-TsOH / CH2Cl2 / 20 °C 2.2: aq. NH3 / methanol 3.1: macroporous polymer-supported carbonate / CH2Cl2 / 20 °C 3.2: PS-trisamine / CH2Cl2 View Scheme
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
反应条件
hydrogenchloride in 3-methyl-1-butanol 36 h; Heating; Yield given;
参考文献
Giardina; Brasili; Gregori; Massi; Picchio; Quaglia; Melchiorre
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 50 - 55
反应条件
in 3-methyl-1-butanol
12 h; Heating;
参考文献
Manoury; Binet; Dumas; Lefevre-Borg; Cavero
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 19 - 25
参考文献
Eisai Co., Ltd.
Patent: US4707477 A1, 1987 ;
