3,5-二溴-2-噻吩羧醛合成路线 （共 7 条）
反应条件
1: 2,4-dibromo thiophene With lithium diisopropyl amide in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran Cooling with ice/acetone; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2426117 A1, 2012 ;
Location in patent: Page/Page column 14-15 ;
反应条件
diisopropylamine in tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide
参考文献
Alcon Laboratories, Inc.
Patent: US5538966 A1, 1996 ;
反应条件
lithium diisopropyl amide Inert atmosphereSchlenk technique;
参考文献
Ordronneau, Lucie; Boixel, Julien; Aubert, Vincent; Vidal, Matias S.; Moya, Sergio; Aguirre, Pedro; Toupet, Loic; Williams, J. A. Gareth; Le Bozec, Hubert; Guerchais, Veronique
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 979 - 992
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -70 deg C, 10 min, 2.) -70 deg C -> 0 deg C;
参考文献
Hawkins, David W.; Iddon, Brian; Longthorne, Darren S.; Rosyk, Peter J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 19 p. 2735 - 2744
反应条件
tetrahydro-4H-pyran; lithium diisopropyl amide T=-50°C;
参考文献
Froehlich, J.
Bulletin des Societes Chimiques Belges, 1996 , vol. 105, # 10-11 p. 615 - 634
反应条件
hydrogenchloride; lithium diisopropyl amide 1.) THF, hexane, Et2O, -80 deg C, 0.5 h; Yield given. Multistep reaction;
参考文献
Sauter, Fritz; Froehlich, Hannes; Kalt, Wolfram
Synthesis, 1989 , # 10 p. 771 - 773
反应条件
sodium tetrahydroborate in methanol
T=0°C; 0.0833333 h;
参考文献
Yamashita, Mitsuaki; Yamada, Ken-Ichi; Tomioka, Kiyoshi
Journal of the American Chemical Society, 2004 , vol. 126, # 7 p. 1954 - 1955
