7-甲氧基-1,3-苯并二氧戊环-5-乙胺合成路线 (共 7 条)
反应条件
in toluene 4 h; Reflux;
参考文献
PAIN THERAPEUTICS, INC.
Patent: WO2010/51374 A1, 2010 ;
Location in patent: Page/Page column 126 ;
反应条件
1: With hydrogenchloride; hydrogen; platinum(IV) oxide in ethanol; water
T=20°C; P=2068.65 Torr; 18 h;
2: With sodium hydroxide in ethanol; water
pH=13 - 14;
参考文献
PAIN THERAPEUTICS, INC.
Patent: WO2010/51374 A1, 2010 ;
Location in patent: Page/Page column 126 ;
反应条件
sulfuric acid; palladium; acetic acid
Hydrogenation;
参考文献
Kindler; Brandt
Archiv der Pharmazie (Weinheim, Germany), 1935 , vol. 273, p. 478,482
反应条件
1: concentrated aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Acetanhydrid
2: palladium; acetic acid; concentrated sulfuric acid / Hydrogenation
View Scheme
参考文献
Kindler
Archiv der Pharmazie (Weinheim, Germany), 1931 , vol. 269, p. 70,76
反应条件
1: aqueous ethanol; hydroxylamine
2: acetic acid anhydride
3: Raney nickel; ammonia; methanol / 100 °C / 22065.2 Torr / Hydrogenation
View Scheme
参考文献
Redemann et al.
Journal of Organic Chemistry, 1948 , vol. 13, p. 886,888
反应条件
1: ethyl acetate; ozone; palladium/calcium carbonate / -12 °C / Erwaermen des Reaktionsprodukts mit Methanol, Hydroxylamin-hydrochlorid und wss. Kalilauge
2: acetic acid anhydride
3: palladium; sulfuric acid; acetic acid / Hydrogenation
View Scheme
参考文献
Hahn; Schales
Chemische Berichte, 1934 , vol. 67, p. 1486,1490
Chemische Berichte, 1935 , vol. 68, p. 24,27
参考文献
National University Corporation Hokkaido University
Patent: EP1974732 A1, 2008 ;
Location in patent: Page/Page column 9 ;