1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: o-(trifluoromethyl)phenylboronic acid With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: 2-Methoxyphenyl-dihydroxyborane With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: 3,4-(methylenedioxy)phenylboronic acid With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: 3-trifluoromethyl-phenoxy-boronic acid With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: [3-(hydroxymethyl)phenyl]boronic acid With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: C15H17BO2S With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 747 - 749
dihydrogen peroxide in tetrahydrofuran; pyridine T=5 - 10°C; Yields of byproduct given;
参考文献
McCague, Raymond; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2399 - 2407
Berry, Jane M.; Watson, Corrine Y.; Whish, William J. D.; Threadgill, Michael D.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1147 - 1156
