3,4-(亚甲二氧)肉桂酸合成路线 （共 62 条）
参考文献
Schwenk; Papa
Journal of Organic Chemistry, 1945 , vol. 10, p. 232,234
反应条件
toluene-4-sulfonic acid in methanol 6 h;
参考文献
LOTUS PHARMACEUTICAL CO., LTD.
Patent: US2009/143397 A1, 2009 ;
Location in patent: Page/Page column 3; 6-7 ;
反应条件
hydrogen; palladium on activated charcoal in N,N-dimethyl-formamide P=760 Torr; 24 h;
参考文献
Charlton, James L.; Chee, Gaik-Lean
Canadian Journal of Chemistry, 1997 , vol. 75, # 8 p. 1076 - 1083
参考文献
Schwenk; Papa
Journal of Organic Chemistry, 1945 , vol. 10, p. 232,234
反应条件
1: 100 percent / H2 / Pd/C / dimethylformamide / 24 h / 760 Torr
2: 1.) pivaloyl chloride, 2.) BuLi
3: 1.) NaHMDS / 1.) THF, -73 deg C, 1 h, 2.) THF, 2 h
4: 30percent aq.H2O2, LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature
5: BH3*THF / 4 h / Ambient temperature
6: TFA / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Bode; Doyle; Protopopova; Zhou
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155
反应条件
sulfuric acid
4 h; Cooling with iceReflux;
参考文献
Prashanth; Revanasiddappa, Hosakere D.; Lokanatha Rai; Veeresh
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7065 - 7070
反应条件
1: 10 palladium on activated charcoal; hydrogen
2: oxalyl dichloride / dichloromethane
3: tin(IV) chloride
4: hydrogenchloride; n-Pentyl nitrite / methanol; water
5: p-toluenesulfonyl chloride; sodium hydroxide / water
View Scheme
参考文献
Wu, Meng; Li, Ling; Feng, An-Zheng; Su, Bo; Liang, De-Min; Liu, Yu-Xiu; Wang, Qing-Min
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2539 - 2542
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
1.5 h; Heating;
参考文献
Bode; Doyle; Protopopova; Zhou
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
32 h;
参考文献
Bailey, Patrick D.; Morgan, Keith M.; Smith, David I.; Vernon, John M.
Tetrahedron, 2003 , vol. 59, # 18 p. 3369 - 3378
反应条件
1: With hydrogen; 5-palladium/activated carbon
T=25°C; 6 h;
2: With thionyl chloride in ethanol
T=5°C; 4 h;
参考文献
KANEKA CORPORATION
Patent: EP1568679 A1, 2005 ;
Location in patent: Page/Page column 9 ;
