3,4-(亚甲二氧)肉桂酸合成路线 （共 62 条）
反应条件
1: With oxalyl dichloride in tetrahydrofuran; DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 3.25 h;
2: With ammonia in tetrahydrofuran; DMF (N,N-dimethyl-formamide); water
T=0 - 5°C; 0.75 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/85434 A1, 2004 ;
Location in patent: Page 18 ;
反应条件
1: (E)-3-(benzo[1,3]dioxol-5-yl)acrylic acid With N-bromosuccinmide; tetrabutyl-ammonium trifluoroacetate in 1,2-dichloro-ethane
T=20°C; Decarboxylation; bromination; Hunsdiecker reaction; 4 h;
2: N-(2-methylpropyl)prop-2-enamide With palladium diacetate; tri-phenyl-antimony; triethylamine in 1,2-dichloro-ethane
Heck reaction; 20 h;
参考文献
Naskar, Dinabandhu; Roy, Sujit
Tetrahedron, 2000 , vol. 56, # 10 p. 1369 - 1377
