4-氨基-3-羟基苯甲酸合成路线 （共 25 条）
反应条件
hydrogenchloride; tin
参考文献
Justus Liebigs Annalen der Chemie, , vol. 311, p. 55
DE97335 ;
反应条件
1: K2S2O8; aqueous KOH 2: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 980,984
反应条件
durch Austausch von NH2 gegen Cl;
参考文献
Beyer
Recueil des Travaux Chimiques des Pays-Bas, 1921 , vol. 40, p. 625
参考文献
Brenans; Prost
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1924 , vol. 178, p. 1286
反应条件
1: 82 percent / HCl / Heating 2: 86 percent / NaNO2; KI; HCl / 0 °C 3: 100 percent / NaH / 20 °C View Scheme
参考文献
Nguyen, Diem N.; Stump, Craig A.; Walsh, Eileen S.; Fernandes, Christine; Davide, Joseph P.; Ellis-Hutchings, Michelle; Robinson, Ronald G.; Williams, Theresa M.; Lobell, Robert B.; Huber, Hans E.; Buser, Carolyn A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1269 - 1273
反应条件
1.1: 5 h / 100 °C / Inert atmosphere 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere 3.1: 3 h / 20 °C / Inert atmosphere 4.1: [2,2']bipyridinyl; [Ni0(1,5-cyclooctadiene)2]; lithium tert-butylate / ethylene glycol dimethyl ether / 24 h / 100 °C / Inert atmosphere 5.1: pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 5.2: Inert atmosphere 5.3: Inert atmosphere View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168014 A1, 2013 ;
反应条件
hydrogenchloride T=0 - 20°C; 48 h;
参考文献
ALMIRALL, S.A.; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; PUIG DURAN, Carlos
Patent: WO2013/68554 A1, 2013 ;
Location in patent: Page/Page column 80 ;
参考文献
Merck and Co., Inc.
Patent: US6297239 B1, 2001 ;
US 6297239 B1
反应条件
in methanol T=10 - 20°C; 48 h; Cooling with ice;
参考文献
Jonckers, Tim H.M.; Rouan, Marie-Claude; Hache, Geerwin; Schepens, Wim; Hallenberger, Sabine; Baumeister, Judith; Sasaki, Jennifer C.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 4998 - 5002
反应条件
1: potassium carbonate 2: NaOH-solution / 100 °C View Scheme
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1921 , vol. 119, p. 1431
