4-溴-2,6-二甲基苯酚合成路线 （共 34 条）
反应条件
in N,N-dimethyl-formamide
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
1: dimethylformamide 2: (i) (hydrolysis), (ii) /BRN= 1098229/, H2SO4 View Scheme
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
potassium carbonate in acetone T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/59954 A1, 2011 ;
Location in patent: Page/Page column 74 ;
US 20110059954 A1
反应条件
1: 4-bromo-2,6-dimethyl-phenol With potassium carbonate in N,N-dimethyl-formamide 0.333333 h; 2: benzyl chloride in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/100026 A1, 2006 ;
Location in patent: Page/Page column 89 ;
WO 2006/100026 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: EP1770087 A1, 2007 ;
EP 1770087 A1
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in dichloromethane; water
参考文献
Morimoto, Toshiaki; Chiba, Mitsuo; Achiwa, Kazuo
Tetrahedron Letters, 1989 , vol. 30, # 6 p. 735 - 738
反应条件
1: 4-bromo-2,6-dimethyl-phenol With sodium hydride in dimethyl sulfoxide T=0°C; 0.916667 h; Inert atmosphere; 2: methyl iodide in dimethyl sulfoxide T=0 - 20°C; 5.66667 h; Inert atmosphere;
参考文献
Sookcharoenpinyo, Bunyarithi; Klein, Emmanuel; Ferrand, Yann; Walker, D. Barney; Brotherhood, Peter R.; Ke, Chenfeng; Crump, Matthew P.; Davis, Anthony P.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 19 p. 4586 - 4590
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6573289 B1, 2003 ;
反应条件
1: With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 18 h; 2: 4-bromo-2,6-dimethyl-phenol; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane With triethylamine in 1,4-dioxane T=100°C; 336 h;
参考文献
US6680401 B1, ;
Page column 68 ;
反应条件
1: 93 percent / NaOH / Bu4N*I / CH2Cl2; H2O 2: 63 percent / Mg / tetrahydrofuran 3: 63 percent / HSiCl3 / toluene View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 6 p. 735 - 738
