3-氨基-5-苯基-1H-吡咯-2-羧酸乙酯合成路线 （共 6 条）
反应条件
sodium ethanolate in tetrahydrofuran; ethanol T=20°C; Addition; cyclization; decarboxylation; 2 h;
参考文献
Chen, Ning; Lu, Yuelie; Gadamasetti, Kumar; Hurt, Clarence R.; Norman, Mark H.; Fotsch, Christopher
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2603 - 2605
反应条件
1: 57 percent / Et3N / CH2Cl2 / 23 h / 0 - 22 °C 2: NaOEt / ethanol / 2 h / 20 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: With acetic acid T=20°C; 15 h; 2: 2 h; Heating; Further stages.;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: in benzene T=90°C; 1 h; 2: With potassium hydroxide T=100°C; 15 h; Further stages.;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: AcOH / methanol / 28 h / 20 °C 2.1: TFA / CH2Cl2 / 4.5 h / 20 °C 2.2: 61 percent / 1N aq. NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: aq. AcOH / 15 h / 20 °C 1.2: 77 percent / 6percent aq. NaOH / 2 h / Heating 2.1: 40 percent / POCl3 / 60 h / 120 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
