2,4-二氯-6-苯基-5H-吡咯并[3,2-d]嘧啶合成路线 （共 4 条）
反应条件
trichlorophosphate T=120°C; 60 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: 57 percent / Et3N / CH2Cl2 / 23 h / 0 - 22 °C 2.1: NaOEt / ethanol / 2 h / 20 °C 3.1: aq. AcOH / 15 h / 20 °C 3.2: 77 percent / 6percent aq. NaOH / 2 h / Heating 4.1: 40 percent / POCl3 / 60 h / 120 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: NaOEt / ethanol / 2 h / 20 °C 2.1: aq. AcOH / 15 h / 20 °C 2.2: 77 percent / 6percent aq. NaOH / 2 h / Heating 3.1: 40 percent / POCl3 / 60 h / 120 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: aq. AcOH / 15 h / 20 °C 1.2: 77 percent / 6percent aq. NaOH / 2 h / Heating 2.1: 40 percent / POCl3 / 60 h / 120 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
