1-溴-4-(1-丙炔-1-基)苯合成路线 （共 9 条）
反应条件
1: 1-bromo-4-ethynylbenzene With sodium hexamethyldisilazane in tetrahydrofuran T=-30°C; 0.25 h; 2: methyl iodide in tetrahydrofuran T=-20 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; DZIERBA, Carolyn, Diane; BRONSON, Joanne, J.; FINK, Cynthia; GREEN, Michael; KIMBALL, David; MACOR, John, E.; KWON, Soojin; ZHANG, Yulian; ZIPP, Greg
Patent: WO2011/44212 A1, 2011 ;
Location in patent: Page/Page column 30-31 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine in tetrahydrofuran T=20°C; 18 h; Inert atmosphere;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 145; 146 ;
反应条件
t-Bu-XantPhos; dichloro bis(acetonitrile) palladium(II); potassium carbonate; cesium fluoride in toluene T=100°C; 20 h; Inert atmosphere;
参考文献
Liu, Yan-Yun; Yang, Xu-Heng; Huang, Xiao-Cheng; Wei, Wen-Ting; Song, Ren-Jie; Li, Jin-Heng
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10421 - 10426
反应条件
pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide T=20°C; 3 h;
参考文献
Songis, Olivier; Misek, Jiri; Schmid, Markus B.; Kollarovic, Adrian; Stara, Irena G.; Saman, David; Cisarova, Ivana; Stary, Ivo
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 6889 - 6899
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride 24 deg C, then 65 deg C;
参考文献
Pschirer, Neil Gregory; Bunz, Uwe H. F.
Tetrahedron Letters, 1999 , vol. 40, # 13 p. 2481 - 2484
反应条件
1: Br2 / 336 h 2: KOH / ethanol / Heating View Scheme
参考文献
Hamer,D.; Magee,W.R.
Journal of the Chemical Society, 1964 , p. 1847 - 1848
反应条件
1: EtCO2Na / 170 °C 2: Br2 / 336 h 3: KOH / ethanol / Heating View Scheme
参考文献
Hamer,D.; Magee,W.R.
Journal of the Chemical Society, 1964 , p. 1847 - 1848
反应条件
(i) PCl5, (ii) KOH, EtOH; Multistep reaction;
参考文献
D'yakonov,I.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1969 , vol. 5, p. 1200 - 1205
Zhurnal Organicheskoi Khimii, 1969 , vol. 5, p. 1227 - 1232
反应条件
hexacarbonyl molybdenum; 4-chloro-phenol in various solvent(s) T=140°C;
参考文献
Pschirer, Neil Gregory; Bunz, Uwe H. F.
Tetrahedron Letters, 1999 , vol. 40, # 13 p. 2481 - 2484
