(R)-(-)-对甲基苯磺酸-2,2-二甲基-1,3-二氧戊环基-4-甲酯合成路线 （共 14 条）
反应条件
1: 82 percent / NaN3 / dimethylformamide / 12 h / 70 °C
2: H2 / 5percent Pd-C / methanol / 5 h / 2250.2 Torr / Ambient temperature
View Scheme
参考文献
Doboszewski, Bogdan; Groaz, Elisabetta; Herdewijn, Piet
European Journal of Organic Chemistry, 2013 , # 22 p. 4804 - 4815
反应条件
sodium azide in dimethyl sulfoxide
T=100°C;
参考文献
Lepine, Renaud; Carbonnelle, Anny-Claude; Zhu, Jieping
Synlett, 2003 , # 10 p. 1455 - 1458
反应条件
sodium hydroxide; sodium in 2-methoxy-ethanol; water
参考文献
Societe Anonyme: Sanofi
Patent: US4806655 A1, 1989 ;
反应条件
1: n-hexadecyl mercaptane With sodium ethanolate in benzene
0.5 h; Inert atmosphere;
2: (R)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methyl-benzenesulfonate T=20°C; Reflux; Product distribution / selectivity;
参考文献
VASCULAR BIOGENICS LTD.; KOVALEVSKI-ISHAI, Eti; ZINIUK, Zeev; HALPERIN, Gideon; MENDEL, Itzhak; FEIGE, Erez; YACOV, Niva; BREITBART, Eyal
Patent: WO2010/52718 A1, 2010 ;
Location in patent: Page/Page column 146-147 ;
