3-(4-羟基苯基)丙酸乙酯合成路线 （共 21 条）
反应条件
thionyl chloride T=20°C;
参考文献
Dandepally, Srinivasa Reddy; Williams, Alfred L.
Tetrahedron Letters, 2010 , vol. 51, # 44 p. 5753 - 5756
反应条件
formic acid; ammonium formate; palladium 10 on activated carbon in water; ethyl acetate T=80°C; 3 h;
参考文献
WO2012/121659 A1, ;
Page/Page column 15 ;
反应条件
ammonium formate; palladium 10 on activated carbon in water; ethyl acetate T=80°C; 2 h;
参考文献
WO2012/121659 A1, ;
Page/Page column 14-15 ;
反应条件
thionyl chloride in ethanol
参考文献
Jeppesen, Lone; Bury, Paul Stanley; Mogensen, John Patrick; Pettersson, Ingrid; Sauerberg, Per
Patent: US2003/139473 A1, 2003 ;
US 20030139473 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature; Title compound not separated from byproducts;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 30, # 4 p. 585 - 589
反应条件
1: 6.2 g / sodium ethoxide / diethyl ether / 5 h / Heating; reflux 2: H2 / 10percent palladium on charcoal / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 30, # 4 p. 585 - 589
反应条件
ethanol T=100°C; im Druckrohr;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 102, p. 151
Journal fuer Praktische Chemie (Leipzig), , vol. <1> 72, p. 404
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C 2.1: piperidine; acetic acid / toluene / Reflux 3.1: water / tetrahydrofuran 3.2: 100 °C 4.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 5.1: acetic acid / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 1267 - 1270
反应条件
1.1: piperidine; acetic acid / toluene / Reflux 2.1: water / tetrahydrofuran 2.2: 100 °C 3.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 4.1: acetic acid / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 1267 - 1270
反应条件
1.1: water / tetrahydrofuran 1.2: 100 °C 2.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 3.1: acetic acid / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 1267 - 1270
