3-(4-羟基苯基)丙酸乙酯合成路线 （共 21 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 2: acetic acid / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 1267 - 1270
反应条件
1: ammonia / 120 °C 2: sodium hypochlorite View Scheme
参考文献
Bayer and Co.
Patent: DE233551 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 1231
反应条件
1: 89.1 percent / K2CO3; NaI / acetone / 48 h / Heating 2: 66.2 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Louis, Simon N.; Nero, Tracy L.; Iakovidis, Dimitri; Colagrande, Felicia M.; Jackman, Graham P.; Louis, William J.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 919 - 937
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating / reflux; 2: With ethyl acetate; sodium sulfate in tetrahydrofuran; water 3: With hydrogenchloride in tetrahydrofuran; water pH=7.0;
参考文献
DR. REDDY'S LABORATORIES LTD.
Patent: WO2005/40102 A2, 2005 ;
Location in patent: Page/Page column 55-56 ;
WO 2005/040102 A2
反应条件
1: K2CO3 / butan-2-one 2: diphenyl ether / 240 °C View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Freeman, Susan; McTaggart, Fergus; Mirrlees, Donald J.; Reid, Alan C.; Smith, Graham J.; Taylor, Melvyn J.; Thomason, Douglas A.; Whittamore, Paul R. O.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 597 - 600
反应条件
potassium carbonate; sodium iodide in acetone
Etherification; 48 h; Heating;
参考文献
Louis, Simon N.; Nero, Tracy L.; Iakovidis, Dimitri; Colagrande, Felicia M.; Jackman, Graham P.; Louis, William J.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 919 - 937
参考文献
Hlasiwetz
Justus Liebigs Annalen der Chemie, 1857 , vol. 102, p. 151
Journal fuer Praktische Chemie (Leipzig), 1857 , vol. <1> 72, p. 404
反应条件
1: K2CO3 / acetone / 20 h / Heating
2: methanol / 4 h / Heating
View Scheme
参考文献
Erhardt, Paul W.; Woo, Chi M.; Anderson, William G.; Gorczynski, Richard J.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1408 - 1412
反应条件
potassium carbonate in butanone
参考文献
Zeneca Limited
Patent: US5919793 A1, 1999 ;
反应条件
potassium carbonate in butanone
参考文献
Brown, George R.; Foubister, Alan J.; Freeman, Susan; McTaggart, Fergus; Mirrlees, Donald J.; Reid, Alan C.; Smith, Graham J.; Taylor, Melvyn J.; Thomason, Douglas A.; Whittamore, Paul R. O.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 597 - 600
