5-溴-3-氰甲基苯并[b]噻吩合成路线 （共 5 条）
反应条件
in ethanol; dichloromethane; water; ethyl acetate
参考文献
ELI LILLY AND COMPANY
Patent: EP835869 A2, 1998 ;
反应条件
in dimethyl sulfoxide T=60°C; 1 h;
参考文献
Leclerc; Beaurain; Depreux; Bennejean; Delagrange; Boutin; Lesieur
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 61 - 65
反应条件
1: 56 percent / dibenzoyl peroxide; N-bromosuccinimide / CCl4 / 4 h / Irradiation; reflux 2: 70 percent / dimethylsulfoxide / 1 h / 60 °C View Scheme
参考文献
Leclerc; Beaurain; Depreux; Bennejean; Delagrange; Boutin; Lesieur
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 61 - 65
反应条件
1: 71 percent / phosphorus pentoxide; polyphosphoric acid / 3 h / 180 °C 2: 56 percent / dibenzoyl peroxide; N-bromosuccinimide / CCl4 / 4 h / Irradiation; reflux 3: 70 percent / dimethylsulfoxide / 1 h / 60 °C View Scheme
参考文献
Leclerc; Beaurain; Depreux; Bennejean; Delagrange; Boutin; Lesieur
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 61 - 65
反应条件
1: 80 percent / pyridine / diethyl ether / 3 h 2: 71 percent / phosphorus pentoxide; polyphosphoric acid / 3 h / 180 °C 3: 56 percent / dibenzoyl peroxide; N-bromosuccinimide / CCl4 / 4 h / Irradiation; reflux 4: 70 percent / dimethylsulfoxide / 1 h / 60 °C View Scheme
参考文献
Leclerc; Beaurain; Depreux; Bennejean; Delagrange; Boutin; Lesieur
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 61 - 65
