5-溴-3-氰基-2-羟基-4,6-二甲基吡啶合成路线 （共 5 条）
反应条件
bromine in acetic acid 0.5 h;
参考文献
Thompson, Wayne J.; Gaudino, John
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5237 - 5243
反应条件
1: 85 percent / ammonium acetate / 3 h / Ambient temperature 2: 92 percent / bromine, glacial acetic acid / 0.17 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 12 p. 983 - 986
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 12 p. 1459 - 1463
反应条件
hydrogenchloride in N,N-dimethyl-formamide; trichlorophosphate
参考文献
FMC Corporation
Patent: US5532370 A1, 1996 ;
反应条件
1: 86 percent / POCl3/PCl5 / 8 h / Heating
2: 62 percent / 47percent aqueous HI/red phosphorus / 4 h / 140 °C
3: 4.5 g / KOH / H2O / 72 h / Heating
View Scheme
参考文献
Thompson, Wayne J.; Gaudino, John
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5237 - 5243
反应条件
1: 86 percent / POCl3/PCl5 / 8 h / Heating
2: 62 percent / 47percent aqueous HI/red phosphorus / 4 h / 140 °C
View Scheme
参考文献
Thompson, Wayne J.; Gaudino, John
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5237 - 5243
