2-氨基-5-甲氧基苯甲腈合成路线 （共 14 条）
反应条件
aluminium trichloride; boron trichloride; potassium carbonate 1.) C6H6, room temp., 20 h, 2.) CH3OH, reflux, 2.5 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 20, # 1 p. 71 - 84
参考文献
Ciba-Geigy Corporation
Patent: US4713383 A1, 1987 ;
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-5-methoxybenzonitrile in chlorobenzene T=120°C; 6 h;
参考文献
Heterocycles, , vol. 85, # 6 p. 1417 - 1426
反应条件
1: ethyl bromide With magnesium in tetrahydrofuran
0.833333 h; Inert atmosphereReflux;
2: 2-amino-5-methoxybenzonitrile in tetrahydrofuran
T=5 - 20°C;
3: With hydrogenchloride; water in tetrahydrofuran
T=0 - 20°C;
参考文献
Xiong, Xiao-Dong; Chen, Wen-Xue; Kuang, Yun-Yan; Chen, Fen-Er
Organic Preparations and Procedures International, 2009 , vol. 41, # 5 p. 423 - 427
