4-(3-甲氧基-3-氧代丙基)-3,5-二甲基-1H-吡咯-2-羧酸乙酯合成路线 （共 12 条）
反应条件
ammonium cerium(IV) nitrate in methanol; water T=20°C; 3 h;
参考文献
Bobal; Lightner
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1219 - 1221
反应条件
sodium hydroxide in ethanol; water 2.5 h;
参考文献
Paine, John B.; Hiom, John; Dolphin, David
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2796 - 2802
反应条件
1: sodium / 100 °C / 13 Torr 2: methanol; sodium View Scheme
参考文献
Hayes et al.
Journal of the Chemical Society, 1958 , p. 3779,3782
反应条件
N-benzyl-trimethylammonium hydroxide in methanol; acetonitrile
2.5 h; Heating;
参考文献
Ganske, Jane A.; Pandey, Ravindra K.; Postich, Michael J.; Snow, Kevin M.; Smith, Kevin M.
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4801 - 4807
反应条件
acetic acid
3.5 h; Heating / reflux;
参考文献
SANOFI PASTEUR SA
Patent: US2008/242857 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
1: 1.) KOH / 1.) DMSO, 15 min, RT, 2.) 2 h, RT
2: 1.) mercury(II) acetate, 2.) triethylamine, LiPdCl3 / 1.) THF, CH3OH, 1 h, RT, 2.) CH3CN, 45 min, 50 deg C
3: 95 percent / H2 / Pd-C / ethanol / 18 h / 760 Torr / Ambient temperature
4: 77 percent / Triton B / acetonitrile; methanol / 2.5 h / Heating
View Scheme
参考文献
Ganske, Jane A.; Pandey, Ravindra K.; Postich, Michael J.; Snow, Kevin M.; Smith, Kevin M.
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4801 - 4807
反应条件
acetic acid
Heating;
参考文献
Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5598 - 5604
反应条件
acetic acid; zinc
T=50°C; 11 h;
参考文献
Cheng, Lingjiang; Lightner, David A.
Synthesis, 1999 , # 1 p. 46 - 48
反应条件
acetic acid; zinc
1 h; Heating;
参考文献
Berezin, M. V.; Semeikin, A. S.; V'yugin, A. I.; Krestov, G. A.
Russian Chemical Bulletin, 1993 , vol. 42, # 3 p. 449 - 453
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 3 p. 495 - 499
参考文献
Fischer et al.
Justus Liebigs Annalen der Chemie, 1930 , vol. 481, p. 159,191
