4,7-二甲氧基-1H-吲哚合成路线 （共 16 条）
反应条件
1: 1) CH3CH2MgBr / 1) ether, 20 min., reflux; 2) 3 h, reflux
2: 0.413 g / AlCl3 / 15 h / 100 °C
View Scheme
参考文献
Malesani, Giorgio; Chiarelotto, Gianfranco; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 613 - 618
反应条件
1: 1) CH3CH2MgBr / 1) ether, 15 min., reflux; 2) 5 h, reflux
2: 0.31 g / AlCl3 / benzene / 5 h / Heating
3: thionyl chloride / benzene / 12 h / Heating
View Scheme
参考文献
Malesani, Giorgio; Chiarelotto, Gianfranco; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 613 - 618
反应条件
1.1: 82 percent / NaH / tetrahydrofuran / 4 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
2.2: 70 percent / tetrahydrofuran / -78 - 20 °C
3.1: 76 percent / ceric (IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Mahboobi, Siavosh; Sellmer, Andreas; Eichhorn, Emerich; Beckers, Thomas; Fiebig, Heinz-Herbert; Kelter, Gerhard
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 85 - 92
反应条件
1: acetic acid / H2O / 3 h / 20 °C
2: CH2Cl2; toluene / 20 °C
3: 5.67 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4: LiAlH4 / diethyl ether; CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Beneteau, Valerie; Besson, Thierry
Tetrahedron Letters, 2001 , vol. 42, # 14 p. 2673 - 2676
反应条件
trichlorophosphate
T=20°C; Vilsmeier-Haack reaction; 12 h; Cooling with ice;
参考文献
Kashid; Dube; Alkutkar; Bothara; Mokale; Dhawale
Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4633 - 4640
反应条件
1: 4,7-Dimethoxy-1H-indole With diethylaluminium chloride in hexane; dichloromethane
T=0°C; 0.5 h;
2: acetyl chloride in hexane; dichloromethane
T=50°C; 0.166667 h; microwave irradiation; Further stages.;
参考文献
De Luca, Laura; Barreca, Maria Letizia; Ferro, Stefania; Iraci, Nunzio; Michiels, Martine; Christ, Frauke; Debyser, Zeger; Witvrouw, Myriam; Chimirri, Alba
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 9 p. 2891 - 2895
