N-Boc-N'-Cbz-L-赖氨酸合成路线 （共 32 条）
反应条件
1: ClCO2Et 2: AgO2CCF3 View Scheme
参考文献
Cheng, Jianjun; Ziller, Joseph W.; Deming, Timothy J.
Organic Letters, 2000 , vol. 2, # 13 p. 1943 - 1946
反应条件
1: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr 2: dimethylformamide / 120 h / Ambient temperature View Scheme
参考文献
Acosta, C. Kirk; Bahr, Martin L.; Burdett, James E.; Cessac, James W.; Martinez, Rudy A.; et al.
Journal of Chemical Research, Miniprint, 1991 , # 5 p. 914 - 934
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
dicyclohexyl-carbodiimide 1.) EtOAc, 25 deg C, 3 h, 2.) Et2O, overnight;
参考文献
Rosowsky, Andre; Wright, Joel E.
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5551 - 5558
反应条件
dimethylsulfide; hydrogen fluoride T=0°C; 2 h; Var.: HF in anisole; Product distribution;
参考文献
Tam, James P.; Heath, William F.; Merrifield, R. B.
Tetrahedron Letters, 1982 , vol. 23, # 43 p. 4435 - 4438
反应条件
1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C 2: 74 g / H2 / Pd-C / ethyl acetate / 8 h View Scheme
参考文献
Kawabata, Takeo; Matsuda, Seiji; Kawakami, Shimpei; Monguchi, Daiki; Moriyama, Katsuhiko
Journal of the American Chemical Society, 2006 , vol. 128, # 48 p. 15394 - 15395
反应条件
1.1: aq. Cs2CO3 / ethanol / 1 h / 20 °C 1.2: 99 percent / dimethylformamide / 16 h / 50 °C 2.1: HCl / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Bi, Wei; Bi, Yue; Xue, Ping; Zhang, Yanrong; Gao, Xiang; Wang, Zhibo; Li, Meng; Baudy-Floc'H, Michle; Ngerebara, Nathaniel; Michael Gibson; Bi, Lanrong
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1453 - 1462
反应条件
in dichloromethane; trifluoroacetic acid 0.5 h;
参考文献
Chaudhuri; Talwar
Journal of the Indian Chemical Society, 1989 , vol. 66, # 4 p. 255 - 257
反应条件
ammonium formate; palladium on activated charcoal in methanol 0.0833333 h; Ambient temperature;
参考文献
Channe Gowda
Tetrahedron Letters, 2002 , vol. 43, # 2 p. 311 - 313
反应条件
1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C 2: 74 g / H2 / Pd-C / ethyl acetate / 8 h 3: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C 4: HCl / ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Kawabata, Takeo; Matsuda, Seiji; Kawakami, Shimpei; Monguchi, Daiki; Moriyama, Katsuhiko
Journal of the American Chemical Society, 2006 , vol. 128, # 48 p. 15394 - 15395
