Ethyl 5-氨基-4-氰基-3-甲基-2-噻吩羧酸乙酯合成路线 （共 3 条）
反应条件
piperidine; sulfur in ethanol 3 h; Heating;
参考文献
Elnagdi, Mohamed Hilmy; Erian, Ayman Wahba
Liebigs Annalen der Chemie, 1990 , # 12 p. 1215 - 1219
反应条件
1: With morpholine in N,N-dimethyl-formamide T=25 - 35°C; 2: With sulfur in N,N-dimethyl-formamide T=25 - 55°C; 3: With water in N,N-dimethyl-formamide T=25 - 55°C;
参考文献
WO2011/124992 A1, ;
Page/Page column 19 ;
反应条件
hydrogen bromide; acetic acid
参考文献
Manhas,M.S. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 1937 - 1939
