6-氟-1(3h)-异苯并呋喃酮合成路线 （共 6 条）
反应条件
calcium carbonate in 1,4-dioxane; water 2.5 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; DELUCCA, George V.; BATT, Douglas G.; LIU, Qingjie
Patent: WO2011/159857 A1, 2011 ;
Location in patent: Page/Page column 90-91 ;
WO 2011/159857 A1
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; palladium diacetate in 1,4-dioxane T=180°C; 0.5 h; microwave irradiation;
参考文献
Wu, Xiongyu; Mahalingam; Wan, Yiqian; Alterman, Mathias
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4635 - 4638
反应条件
1: With hydrogenchloride; sodium nitrite in water T=5°C; 0.5 h; 2: With tetrafluoroboric acid in water T=5°C; Schiemann reaction; 1 h;
参考文献
Wang, Wei; Cha, Xue-Xiang; Reiner, John; Gao, Yuan; Qiao, Hai-Ling; Shen, Jia-Xiang; Chang, Jun-Biao
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1941 - 1946
反应条件
[Cp*Ir(6,6’-(OH)2bpy)(H2O)][OTf]2 in water 6 h; Inert atmosphereRefluxGreen chemistry; Overall yield = 94 percent;
参考文献
Fujita, Ken-Ichi; Ito, Wataru; Yamaguchi, Ryohei
ChemCatChem, 2014 , vol. 6, # 1 p. 109 - 112
参考文献
Russel, Richard A.; Pilley, Boyd A.; Warrener, Ronald N.
Synthetic Communications, 1986 , vol. 16, # 4 p. 425 - 430
反应条件
1.1: potassium hydroxide; water / methanol / 1.5 h / Reflux
1.2: pH 3 - 4
2.1: manganese(IV) oxide / tetrahydrofuran / 16 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; DELUCCA, George V.; BATT, Douglas G.; LIU, Qingjie
Patent: WO2011/159857 A1, 2011 ;
WO 2011/159857 A1
