1,3,6-三甲基-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲醛合成路线 （共 4 条）
参考文献
GLENMARK PHARMACEUTICALS, S.A.; KUMAR, Sukeerthi; THOMAS, Abraham; GAIKWAD, Siddeshwar, Shrimant; MARGAL, Sanjay; PHATANGARE, Shantaram, Kashinath; IRLAPATI, Nageswara, Rao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2010/125469 A1, 2010 ;
Location in patent: Page/Page column 35 ;
WO 2010/125469 A1
反应条件
2: phosphoroxychloride View Scheme
参考文献
Kanatomo; Wada; Yomei; Hase; Nagai; Fukuda; Tanaka; Sasaki
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2042 - 2049
反应条件
1: 29 percent / acetonitrile / 2 h / Heating 2: 85 percent / ethanol / 2 h / Heating View Scheme
参考文献
Hirota, Kosaku; Kitade, Yukio; Shimada, Kaoru; Maki, Yoshifumi
Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1512 - 1516
反应条件
1: 80 percent / Et3N, H2N-OH*HCl / ethanol / 3 h / Ambient temperature 2: 72 percent / pyridine / 3 h / Ambient temperature 3: 97 percent / dimethylformamide / 3 h / 80 °C 4: 58 percent / PPh3 / 24 h / 150 °C View Scheme
参考文献
Hirota, Kosaku; Nakazawa, Yukio; Kitade, Yukio; Sajiki, Hironao
Heterocycles, 1998 , vol. 47, # 2 p. 871 - 882
