5-[(2R)-2-氨基丙基]-1-[3-(苯甲酰氧基)丙基]-2,3-二氢-7-氰基-1H-吲哚合成路线 （共 14 条）
反应条件
sodium hydroxide in water
参考文献
SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar
Patent: WO2013/56842 A1, 2013 ;
Location in patent: Page/Page column 20 ;
反应条件
1: sodium carbonate / ethanol; tert-butyl alcohol / 42 h / 50 - 90 °C 2: sodium hydroxide; water / methanol / 1.25 h / 20 °C / cooling with ice View Scheme
参考文献
SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar
Patent: WO2013/56842 A1, 2013 ;
反应条件
1: 1-(3-benzoyloxypropyl)-7-cyano-5-(2R-aminopropyl)-2,3-dihydroindole With dihydrogen peroxide; sodium hydroxide in dimethyl sulfoxide 2 h; 2: [2-(2,2,2-trifluoroethoxy)phenoxy]acetaldehyde With acetic acid in methanol T=25 - 30°C; 1 h; 3: With sodium cyanoborohydride in methanol T=40 - 45°C; 2 h;
参考文献
SANDOZ AG
Patent: US2012/165548 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
1: sodium carbonate / ethanol; tert-butyl alcohol / 42 h / 50 - 90 °C 2: sodium hydroxide; water / methanol / 1.25 h / 20 °C / cooling with ice 3: sodium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 2.25 h / 20 - 25 °C View Scheme
参考文献
SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar
Patent: WO2013/56842 A1, 2013 ;
