5-(2-羟基乙基)尿嘧啶合成路线 （共 9 条）
反应条件
potassium peroxomonosulphate; silver nitrate in water T=30 - 40°C; 3 h;
参考文献
Tetrahedron, , vol. 50, # 28 p. 8371 - 8380
反应条件
sulfuric acid
T=100°C; 1 h;
参考文献
Fissekis; Sweet
The Journal of organic chemistry, 1973 , vol. 38, # 2 p. 264 - 269
反应条件
pyridine
T=0°C; 5 h;
参考文献
Eger; Jalalian; Schmidt
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 211 - 218
反应条件
1: 51 percent / AgNO3, potassium persulfate / H2O / 3 h / 30 - 40 °C
2: 65 percent / PPh3, Zn dust / CH2Cl2; dimethylformamide / 48 h / Ambient temperature
3: 95 percent / sodium tert.-pentoxide / dimethylformamide / 2 h / -10 °C
View Scheme
参考文献
Eger; Jalalian; Schmidt
Tetrahedron, 1994 , vol. 50, # 28 p. 8371 - 8380
反应条件
1: 1.) triphenylphosphine, 2.) carbon tetrachloride, pyridine / 1.) DMF, 10 min, 2.) DMF, RT, 1.5 h
2: 1.) trimethylchlorosilane, hexamethyldisilazane, 2.) trimethylsilyl triflate / 1.) reflux, 3 h, 2.) CHCl3, RT, 1 h
3: 83 percent / 1N NaOEt / ethanol / Ambient temperature
View Scheme
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
反应条件
pyridine; tetrachloromethane; triphenylphosphine
1.) DMF, 10 min, 2.) DMF, RT, 1.5 h; Yield given. Multistep reaction;
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
反应条件
chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane
1.) reflux, 3 h, 2.) CHCl3, RT, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
反应条件
copper(l) iodide; 1,1,1,3,3,3-hexamethyl-disilazane
参考文献
Zhang, Di; Xu, Liang; Wei, Xia; Li, Yaming; He, Junlin; Liu, Keliang
Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 10 p. 924 - 942
反应条件
1: 51 percent / AgNO3, potassium persulfate / H2O / 3 h / 30 - 40 °C
2: 65 percent / PPh3, Zn dust / CH2Cl2; dimethylformamide / 48 h / Ambient temperature
View Scheme
参考文献
Eger; Jalalian; Schmidt
Tetrahedron, 1994 , vol. 50, # 28 p. 8371 - 8380
