4-氟-1-苯并噻吩-2-羧酸合成路线 （共 7 条）
反应条件
1: With lithium hydroxide hydrate; water in methanol T=20°C; 2: With hydrogenchloride in water pH=1;
参考文献
WO2012/155352 A1, ;
Page/Page column 50 ;
反应条件
1: With potassium hydroxide in water 4 h; Reflux; 2: With hydrogenchloride in water T=20°C; pH=1; 1 h;
参考文献
WO2013/15456 A1, ;
Page/Page column 39 ;
反应条件
hydrogenchloride in water T=60°C;
参考文献
WO2013/15456 A1, ;
Page/Page column 40 ;
反应条件
1: With potassium hydroxide in water 2.5 h; Reflux; 2: With hydrogenchloride in water 1 h;
参考文献
WO2013/15456 A1, ;
Page/Page column 40; 41 ;
反应条件
1.1: sodium acetate / acetic acid / 3 h / |Reflux 2.1: sodium hydroxide; water / 1.5 h / 20 °C 2.2: 0.5 h / 10 °C / |Cooling with ice 3.1: potassium hydroxide / water / 4 h / |Reflux 3.2: 1 h / 20 °C / pH 1 View Scheme
反应条件
1.1: sodium hydroxide; water / 1.5 h / 20 °C 1.2: 0.5 h / 10 °C / |Cooling with ice 2.1: potassium hydroxide / water / 4 h / |Reflux 2.2: 1 h / 20 °C / pH 1 View Scheme
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl acetamide
T=200°C; 1 h; microwave irradiation;
参考文献
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
