1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
tri-tert-butyl phosphine; LiN(Cy)2; bis(dibenzylideneacetone)-palladium(0) in toluene T=20°C; 24 h;
参考文献
Jorgensen, Morten; Lee, Sunwoo; Liu, Xiaoxiang; Wolkowski, Joanna P.; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12557 - 12565
