1: 63 percent / sodamide / tetrahydrofuran / 1.5 h / 50 °C
2: 97 percent / HCl conc. / methanol / 1 h / Heating
3: pyridine
View Scheme
参考文献
Giles, Robin G. F.; Hughes, Andrew B.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 6 p. 1581 - 1587
Bernotas, Ronald C.; Thomas, Craig E.; Carr, Albert A.; Nieduzak, Thaddeus R.; Adams, Ginette; Ohlweiler, David F.; Hay, David A.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 10 p. 1105 - 1110
1: 3-methoxybromobenzene With n-butyllithium in tetrahydrofuran
T=-78°C; 1 h; Sealed tubeInert atmosphere;
2: zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C; Sealed tubeInert atmosphere;
参考文献
Dennis, Joseph M.; Calyore, Catherine M.; Sjoholm, Jessica S.; Lutz, J. Patrick; Gair, Joseph J.; Johnson, Jeffrey B.
Synlett, 2013 , vol. 24, # 19 art. no. ST-2013-S0592-L, p. 2567 - 2570
tris-(dibenzylideneacetone)dipalladium(0); phenolated sodium; di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,1-dimethylpropan-1-ol; water
T=100°C; 1.5 h;
参考文献
Anderson, Kevin W.; Ikawa, Takashi; Tundel, Rachel E.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2006 , vol. 128, # 33 p. 10694 - 10695
