甲基 6-甲氧基-2-萘乙酸酯合成路线 （共 27 条）
反应条件
water in phosphate buffer T=25°C; pH=7.4; Kinetics; Further Variations:TemperaturespH-values;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 6 p. 1292 - 1298
反应条件
1: methyl 2-(6'-methoxy-2'-naphthyl)-acetate With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - -40°C; 2: trideuteriomethyl iodide in tetrahydrofuran T=-78 - -40°C;
参考文献
AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi; GANT, Thomas, G.; SARSHAR, Sepehr
Patent: WO2010/129505 A2, 2010 ;
Location in patent: Page/Page column 37-38 ;
WO 2010/129505 A2
反应条件
1: methyl 2-(6'-methoxy-2'-naphthyl)-acetate With potassium hexamethylsilazane in ethylene glycol dimethyl ether; toluene
T=-78°C;
2: methyl iodide in ethylene glycol dimethyl ether; toluene
T=-78°C; Further stages.;
参考文献
Sarakinos, Georgios; Corey
Organic Letters, 1999 , vol. 1, # 11 p. 1741 - 1744
反应条件
potassium carbonate
T=220°C; 6 h;
参考文献
Bomben, Andrea; Selva, Maurizio; Tundo, Pietro
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 4 p. 256 - 260
反应条件
potassium carbonate
T=220°C; 6 h;
参考文献
Selva, Maurizio; Marques, Carlos Alberto; Tundo, Pietro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1323 - 1328
反应条件
1: LiAlH4 / diethyl ether / Heating
2: PBr3 / benzene / Heating
3: aq. ethanol / Heating
4: diethyl ether / Heating
5: NaBH4 / ethanol
View Scheme
参考文献
Goudie,A.C. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, # 12 p. 1260 - 1264
反应条件
1: LiAlH4 / diethyl ether / Heating
2: PBr3 / benzene / Heating
3: aq. ethanol / Heating
4: diethyl ether / Heating
5: aq. HCl / acetic acid / Heating
View Scheme
参考文献
Goudie,A.C. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, # 12 p. 1260 - 1264
