2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
Novozym 435reg; in acetonitrile
T=45°C; 216 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Morrone; D'Antona; Lambusta; Nicolosi
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 65, # 1-4 p. 49 - 51
反应条件
Novozym 435reg; in acetonitrile
T=45°C; 72 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Morrone; D'Antona; Lambusta; Nicolosi
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 65, # 1-4 p. 49 - 51
反应条件
hydrogenchloride; sodium hydrogencarbonate; aluminium trichloride in dichloromethane; water; 1,3,5-trimethyl-benzene
参考文献
Alfa Chemicals Italiana S.r.l.
Patent: EP440930 A2, 1991 ;
参考文献
EMS S.A.
Patent: US2012/115817 A1, 2012 ;
Location in patent: Page/Page column 43 ;
反应条件
in diethyl ether
T=0°C; 1 h;
参考文献
Hiyama; Inoue
Synthesis, 1986 , vol. NO. 8, p. 689 - 691
反应条件
methanol in hexane; benzene
T=20°C; 0.166667 h;
参考文献
Noji, Masahiro; Sunahara, Haruka; Tsuchiya, Ken-Ichi; Mukai, Toru; Komasaka, Ayako; Ishii, Keitaro
Synthesis, 2008 , # 23 art. no. F16908SS, p. 3835 - 3845
反应条件
ammonium cerium(IV) nitrate in methanol
0.5 h; var. molar ratio of the oxidant; other oxidant; also anodic oxidation; sodium salt of naproxen; Product distribution;
参考文献
Bosca; Martinez-Manez; Miranda; Primo; Soto; Vano
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 5 p. 479 - 482
反应条件
1.1: sulfuric acid / 2 h / |Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
2.2: 0.5 h / -78 - 0 °C / |Inert atmosphere
2.3: 1 h / 0 - 20 °C / |Inert atmosphere
3.1: anhydrous potassium trimethylsilanolate / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Windsor, Matthew A.; Hermanson, Daniel J.; Kingsley, Philip J.; Xu, Shu; Crews, Brenda C.; Ho, Winnie; Keenan, Catherine M.; Banerjee, Surajit; Sharkey, Keith A.; Marnett, Lawrence J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 759 - 763
反应条件
1.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / CH2Cl2 / 0.25 h
1.2: 72 percent / 4-dimethylaminopyridine / CH2Cl2 / 16 h / Heating
2.1: aq. HCl / 65 °C / pH 2
View Scheme
参考文献
Thorsteinsson; Masson, Mar; Loftsson; Haraldsson; Stefansson
Pharmazie, 1999 , vol. 54, # 11 p. 831 - 836
参考文献
Harrison; Lewis; Nelson; Rooks; Roszkowski; Tomolonis; Fried
Journal of medicinal chemistry, 1970 , vol. 13, # 2 p. 203 - 205
