2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
hydrogenchloride; triethylamine in aqueous sodium hydroxide; N-ethyl-D-glucamine salt; chloroform; water; S-(+)-6-methoxy-α-methyl-2-naphthalene acetic acid; isopropyl alcohol
反应条件
1: 86 percent / <bis(dimethylphosphino)ethane>nickel(II) chloride / tetrahydrofuran / Ambient temperature 2: 93 percent / tetrakis(tri-p-tolyl phosphite)nickel(0), tri-p-tolyl phosphite, ionol / toluene 3: 85 percent / KOH, H2O / ethane-1,2-diol / 24 h / 125 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 25 p. 5370 - 5372
反应条件
trifluoroacetic anhydride in tetrahydrofuran
反应条件
sodium hydroxide in water
反应条件
hydrogenchloride; potassium hydroxide; n-butyllithium in tetrahydrofuran; methanol
参考文献
Syntex Pharmaceuticals International Ltd.
Patent: US4723033 A1, 1988 ;
反应条件
potassium hydroxide in acetone 2 h; Heating;
参考文献
Clericuzio, Marco; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Synthesis, 2002 , # 7 p. 921 - 927
反应条件
magnesium in tetrahydrofuran
反应条件
lithium aluminium tetrahydride; titanium tetrachloride in tetrahydrofuran T=-5°C; 0.5 h;
参考文献
Garcia, Mariano; Del Campo, Carmen; Sinisterra, Jose V.; Llama, Emilio F.
Tetrahedron Letters, 1993 , vol. 34, # 49 p. 7973 - 7974
反应条件
potassium permanganate; sodium periodate; potassium carbonate in water; tert-butyl alcohol 0 deg C, 30 min; room temp., 18 h;
参考文献
Hiyama; Inoue
Synthesis, 1986 , vol. NO. 8, p. 689 - 691
反应条件
1: 100 percent / pyridine 2: 43 percent / Sn(OTf)4 / CH2Cl2 / 3.5 h / -78 °C 3: 90 percent / aq. potassium hydroxide / 5 h / Heating View Scheme
参考文献
Synthesis, , vol. NO. 8, p. 689 - 691
