2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
1: DMSO, Ac2O / 24 h / Ambient temperature 2: K2CO3 / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 34 p. 3995 - 3998
反应条件
1: 65 percent / tetrahydrofuran / RT, 1 h; 40 deg C, 2 h; 50 deg C, 1 h 2: 71 percent / potassium hydroxide / ethane-1,2-diol / 8 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 9 p. 3139 - 3148
反应条件
1: 66 percent / I2, Ag2O / dioxane; H2O / 24 h / Ambient temperature 2: chromic acid View Scheme
参考文献
Chemistry Letters, , p. 341 - 344
反应条件
1: 99 percent / KOH / H2O; ethanol / 5 h / 100 °C 2: 1) LDA / 1) hexane, THF, 0 deg C, 30 min, 2) HMPA, -78 deg C -> 0 deg C, 1 h 3: 1) Mg / 1) diethyl ether, 2) rt, 2 h 4: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 5: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 6: 53 percent / DDQ / benzene / 4.7 h / Heating 7: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 8: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 9: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 1) LDA / 1) hexane, THF, 0 deg C, 30 min, 2) HMPA, -78 deg C -> 0 deg C, 1 h 2: 1) Mg / 1) diethyl ether, 2) rt, 2 h 3: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 4: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 5: 53 percent / DDQ / benzene / 4.7 h / Heating 6: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 7: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 8: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
[Ru(acac)2(binap)]; hydrogen in methanol Rate constant;
参考文献
Journal of the American Chemical Society, , vol. 113, # 2 p. 589 - 594
参考文献
Ferrayoli, Carlos G.; Palacios, Sara M.; Alonso, Ruben A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 12 p. 1635 - 1638
反应条件
1: POCl3, i-Pr2NH 2: 600 °C 3: HCl / diethyl ether View Scheme
参考文献
Angewandte Chemie, , vol. 103, # 8 p. 907 - 915
反应条件
1: 600 °C 2: HCl / diethyl ether View Scheme
参考文献
Angewandte Chemie, , vol. 103, # 8 p. 907 - 915
反应条件
1: 53 percent / DDQ / benzene / 4.7 h / Heating 2: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 3: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 4: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
