2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
1: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 2: 53 percent / DDQ / benzene / 4.7 h / Heating 3: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 4: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 5: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 1) Mg / 1) diethyl ether, 2) rt, 2 h 2: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 3: 87 percent / MnO2 / various solvent(s) / 36 h / 180 °C 4: 53 percent / DDQ / benzene / 4.7 h / Heating 5: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 6: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 7: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 91 percent / Et3SiH, CF3CO2H / CH2Cl2 / Ambient temperature 2: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 3: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 77 percent / MnO2 / various solvent(s) / 120 h / 180 °C 2: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 3: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 4: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 75 percent / 5percent aq. HCl / tetrahydrofuran / 19 h / Ambient temperature 2: 91 percent / Et3SiH, CF3CO2H / CH2Cl2 / Ambient temperature 3: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 4: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
1: 1) Mg / 1) diethyl ether, 2) rt, 2 h 2: BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 3: 77 percent / MnO2 / various solvent(s) / 120 h / 180 °C 4: 1) 10 M BH3*SMe2, 2) 10percent aq. NaOH, 30percent aq. H2O2 / 1) THF, 0 deg C, 1 h, 2) rt, 6 h 5: 94 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / -78 °C 6: 50 percent / KMnO4, MgSO4 / acetone / 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 469 - 475
反应条件
Candida rugosa lipase type VII lyophilized from aqueous solution; water in tetrahydrofuran pH=7; Sonicationaq. phosphate bufferEnzymatic reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 81, # 5 p. 617 - 622
反应条件
1: toluene; tetrahydrofuran / 0 - 5 °C / |Inert atmosphere 2: acetic acid; sodium nitrite / dimethyl sulfoxide / 90 - 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 30 p. 3911 - 3915
反应条件
1: ammonium acetate; acetic acid / 90 - 100 °C 2: toluene; tetrahydrofuran / 0 - 5 °C / |Inert atmosphere 3: acetic acid; sodium nitrite / dimethyl sulfoxide / 90 - 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 30 p. 3911 - 3915
反应条件
1.1: sodium hydride / toluene / 5 h / 80 - 90 °C 2.1: hydrogen; 5 palladium on charcoal / toluene / 24 h / 80 °C / 6000.6 Torr 3.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2 3.2: pH 10 4.1: potassium hydroxide / methanol / 72 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
