2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
1.1: ammonia / dichloromethane / 1 h / pH 10 2.1: sodium hydride / toluene / 5 h / 80 - 90 °C 3.1: hydrogen; 5 palladium on charcoal / toluene / 24 h / 80 °C / 6000.6 Torr 4.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2 4.2: pH 10 5.1: potassium hydroxide / methanol / 72 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1.1: hydrogen; 5 palladium on charcoal / toluene / 24 h / 80 °C / 6000.6 Torr 2.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2 2.2: pH 10 3.1: potassium hydroxide / methanol / 72 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2 1.2: pH 10 2.1: potassium hydroxide / methanol / 72 h / |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
Tween 80; potassium chloride in phosphate buffer T=37°C; Hydrolysis; pH=7.4; Kinetics; Further Variations:pH-valuesalso in 80 percent human plasma or 10 percent rat liver homogenate;
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 7-8 p. 551 - 562
反应条件
sodium hydroxide; potassium acetate 1.) 1,3-propanediol, 125 deg C, 8 h, 2.) MeOH, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 5 p. 505 - 506
反应条件
D1E1 lipase; Pseudomonas aeruginosa ACA5 in acetonitrile T=30°C; pH=7.5; 1.5 h; Product distribution; Further Variations:Reagents;
参考文献
Reetz, Manfred T.; Carballeira, Jose Daniel; Peyralans, Jerome; Hoebenreich, Horst; Maichele, Andrea; Vogel, Andreas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6031 - 6038
反应条件
water in acetonitrile T=39°C; pH=7.1; Kinetics;
参考文献
Tetrahedron Letters, , vol. 48, # 26 p. 4609 - 4611
反应条件
1: 95 percent / Raney nickel 2: 95 percent / alkaline hydrolysis View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 14 p. 1531 - 1534
反应条件
Theorell-Stenhagen buffer system in water T=60°C; Hydrolysis; pH=9; 7 h; Kinetics; Further Variations:pH-valuesSolventsReagents;
参考文献
Pharmazie, , vol. 54, # 11 p. 831 - 836
反应条件
sodium hydroxide in ethanol T=65°C; Hydrolysis; Kinetics; Further Variations:pH-valuesReagents;
参考文献
Pharmazie, , vol. 54, # 11 p. 831 - 836
