4,5-二氯-1,2-苯二甲醇合成路线 （共 9 条）
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 24 h; Inert atmosphere;
参考文献
Tuerkmen, Yunus E.; Montavon, Timothy J.; Kozmin, Sergey A.; Rawal, Viresh H.
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9062 - 9065
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
WO2008/151211 A1, ;
Page/Page column 201-202 ;
WO 2008/151211 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2.5 h; Heating;
参考文献
Levy, Louis A.
Synthetic Communications, 1983 , vol. 13, # 8 p. 639 - 648
反应条件
hydrogen bromide in water 4 h; Heating;
参考文献
Levy, Louis A.
Synthetic Communications, 1983 , vol. 13, # 8 p. 639 - 648
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
Powell; Dennis; Paul; Rolf; Hallett; William A.; Berger; Dan M.; Dutia; Minu D.
Patent: US5387685 A1, 1995 ;
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; Inert atmosphere; 2: With triethylamine in dichloromethane T=-78 - 20°C;
参考文献
Miller, Glen P.; Kaur, Irvinder
Patent: US2011/130594 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
Oxonereg;; 2-iodo-3,4,5,6-tetramethylbenzoic acid in nitromethane T=30°C; 10 h; Green chemistry;
参考文献
Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha
Tetrahedron, 2014 , vol. 70, # 13 p. 2286 - 2293
反应条件
1: 77 g / 45percent HBr / H2O / 4 h / Heating 2: 18 g / Na2S*9H2O / 0.5 h 3: 13.4 g / 40percent CH3CO2OH / CHCl3 4: 5.9 g / 7 h / 230 °C 5: 5.4 g / NBS, AIBN / acetic anhydride / 1.5 h / Heating 6: 4.1 g / methanol / 2 h / Heating 7: 2.3 g / Et3N, diphenylphosphoryl azide / 6 h / Heating 8: 1.8 g / HCl / diethyl ether 9: 1.) NaNO2, HCl, 2.) CuCl, HCl / 1.) H2O, 0 deg C View Scheme
参考文献
Levy, Louis A.
Synthetic Communications, 1983 , vol. 13, # 8 p. 639 - 648
