4-甲基-1H-吡咯-2-甲醛合成路线 （共 8 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; Vilsmeier Reaction; Inert atmosphere; 2: 3-methyl pyrrole in dichloromethane T=20°C; 10 h; Inert atmosphere; 3: With sodium hydroxide in water T=20°C; 1 h;
参考文献
Stierle, Donald B.; Faulkner, John D.
Journal of Organic Chemistry, 1980 , vol. 45, # 24 p. 4980 - 4982
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.25 h; 2: 3-methyl pyrrole in 1,2-dichloro-ethane T=0°C; 0.25 h; Heating / reflux; 3: With sodium acetate in water; 1,2-dichloro-ethane T=0°C; 0.333333 h; Heating / reflux;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 95 percent / Na 2: 71 percent / lead tetraacetate / CHCl3 3: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature 4: 31 percent / 2-amino-ethanol / 0.33 h / 200 °C View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
1: 71 percent / lead tetraacetate / CHCl3 2: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature 3: 31 percent / 2-amino-ethanol / 0.33 h / 200 °C View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
1: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature 2: 31 percent / 2-amino-ethanol / 0.33 h / 200 °C View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
1: 60 percent 2: 95 percent / Na 3: 71 percent / lead tetraacetate / CHCl3 4: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature 5: 31 percent / 2-amino-ethanol / 0.33 h / 200 °C View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
in ethanolamine T=200°C; 0.333333 h;
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
hydrogenchloride; diethyl ether und Behandeln des Reaktionsprodukts mit Wasser;
参考文献
Siedel
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1935 , vol. 231, p. 167,184
