2-氨基-3-苄氧基吡啶合成路线 （共 25 条）
参考文献
Kawano, Tomikazu; Kato, Nobuo
Chemistry Letters, 2006 , vol. 35, # 3 p. 270 - 271
参考文献
Tetrahedron Letters, , vol. 26, # 21 p. 2571 - 2574
反应条件
1: sulfuric acid; bromine; acetic acid / water / 0 - 20 °C 2: hydrogenchloride; acetic acid / water / Reflux; Inert atmosphere View Scheme
参考文献
Chen, Dong; Liu, Yajing; Zhang, Shulan; Guo, Dexiang; Liu, Chunhong; Li, Sai; Gong, Ping
Archiv der Pharmazie, 2011 , vol. 344, # 3 p. 158 - 164
反应条件
ammonium hydroxide; trichlorophosphate in water; toluene
参考文献
WATSON LABORATORIES, INC.; CHAVAN, Amit, Anant; BHANU, Manjunath, Narayan; JOSHI, Ashutosh, Vijay
Patent: WO2012/134445 A1, 2012 ;
Location in patent: Page/Page column 26; 27 ;
反应条件
sodium hydrogencarbonate in ethanol; water 8 h; Heating;
参考文献
Rydzkowski, Richard; Blondeau, Dominique; Sliwa, Henri
Journal of Chemical Research, Miniprint, 1986 , # 11 p. 3368 - 3390
反应条件
sodium hydrogencarbonate T=0 - 70°C;
参考文献
ISIS INNOVATION LTD.; EBETINO, Frank, Hallock; MAZUR, Adam; LUNDY, Mark, Walden; RUSSELL, Robert, Graham Goodwin
Patent: WO2010/33978 A2, 2010 ;
Location in patent: Page/Page column 35-36 ;
反应条件
anhydrous sodium hydrogen carbonate in tetrahydrofuran
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4788185 A1, 1988 ;
反应条件
in ethanol 19 h; RefluxSealed tube;
参考文献
ARIAD PHARMACEUTICALS, INC.; GOZGIT, Joseph, M.; RIVERA, Victor, M.; SHAKESPEARE, William, C.; ZHU, Xiaotian; DALGARNO, David, C.
Patent: WO2013/162727 A1, 2013 ;
Location in patent: Page/Page column 65 ;
反应条件
bromine in chloroform T=0°C;
参考文献
Hinklin, Ronald J.; Boyd, Steven A.; Chicarelli, Mark J.; Condroski, Kevin R.; Dewolf, Walter E.; Lee, Patrice A.; Lee, Waiman; Singh, Ajay; Thomas, Laurie; Voegtli, Walter C.; Williams, Lance; Aicher, Thomas D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7669 - 7678
反应条件
1: 70 percent / NaHCO3 / ethanol; H2O / 8 h / Heating 2: Pd(OH)2 / ethanol; cyclohexene / 12 h / Heating View Scheme
参考文献
Rydzkowski, Richard; Blondeau, Dominique; Sliwa, Henri
Journal of Chemical Research, Miniprint, 1986 , # 11 p. 3368 - 3390
