2-氨基-3-苄氧基吡啶合成路线 （共 25 条）
反应条件
1: ethanol / 20 h / Heating
2: 60 percent / hydroxylamine-O-sulfonic acid, pyridine / methanol / 18 h / Heating
3: 86 percent / H2 / 5percent Pd/C / tetrahydrofuran; ethanol
View Scheme
参考文献
Moormann, Alan E.; Pitzele, Barnett S.; Jones, P. H.; Gullikson, Gary W.; Albin, David; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 614 - 626
反应条件
in ethanol
2 h; Reflux;
参考文献
Groselj, Uros; Bezensek, Jure; Meden, Anton; Svete, Jurij; Stanovnik, Branko; Oblak, Marko; Stefanic Anderluh, Petra; Urleb, Uros
Heterocycles, 2008 , vol. 75, # 6 p. 1355 - 1370
反应条件
in ethanol
20 h; Heating;
参考文献
Kaminski, James J.; Bristol, James A.; Puchalski, Chester; Lovey, Raymond G.; Elliott, Arthur J.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 876 - 892
反应条件
1.1: sulfuric acid / 20 °C
1.2: 3.58 h / 0 °C
2.1: copper(l) iodide; iodine; 1,2-dichloro-ethane; isopentyl nitrite / 0.17 h / 85 °C
View Scheme
参考文献
Verdelet, Tristan; Mercey, Guillaume; Correa, Nobi; Jean, Ludovic; Renard, Pierre-Yves
Tetrahedron, 2011 , vol. 67, # 45 p. 8757 - 8762
反应条件
in ethanol
T=100°C; 48 h; Molecular sieve;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; HAßFELD, Jorma; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; LI, Volkhart Min-Jian; BECKER, Eva-Maria; KNORR, Andreas
Patent: US2014/128372 A1, 2014 ;
Location in patent: Paragraph 0489; 0490; 0491; 0492; 0493 ;
